The Future of Herbal Supplements: Exploring Water-Soluble Mitragynine for Enhanced Performance

What is Kratom?

Kratom, a herbal supplement derived from the leaves of the Mitragyna speciosa tree, has gained attention for its potential performance-enhancing properties. One specific compound found in kratom, called mitragynine, has been the focus of research for its potential to improve cognitive function and physical endurance. As the future of herbal supplements unfolds, exploring the benefits and applications of water-soluble mitragynine could lead to significant advancements in enhancing human performance.

What is Mitragynine?

Mitragynine is a compound found in the kratom plant. Nanokinetics® has been focused on exploring the water-soluble form of mitragynine, which shows promise for creating effective, fast-acting, pleasant-tasting, and stable kratom-infused beverages and supplements. This advancement in herbal supplement technology may pave the way for more effective and consistent use of mitragynine in finished products with increased shelf life and stability, while using milk food-grade ingredients. 

Kratom Powder, Kratom Extract, and Water-Soluble Mitragynine: What is the Difference?

Kratom powder, kratom extract, and water-soluble mitragynine each represent different forms of utilizing the psychoactive alkaloids present in kratom leaves, primarily mitragynine and 7-hydroxymitragynine. 

Kratom Powder

Kratom powder is a finely ground substance made from the leaves of the kratom tree (Mitragyna speciosa), which is native to Southeast Asia. The leaves are harvested, dried, and then crushed or ground into a fine powder. Kratom has been traditionally used in its native regions for its stimulant and sedative properties, depending on the dosage. 

Kratom powder contains various alkaloids with mitragynine being the most abundant and responsible for its effects (Huestis, 2024). It is commonly consumed by brewing it as a tea or ingesting the ground leaf powder in capsules. Kratom leaf powder cannot be mixed into drinks as it is not water-soluble.   

Kratom Extract

On the other hand, kratom extract is a concentrated form of the alkaloids of interest and has variable concentrations of mitragynine and 7-hydroxymitragynine (Zhang et al., 2022). 

Kratom extracts are frequently sold in various forms such as capsules and powders. Capsules are a common way to consume those extracts because they have an extremely bitter and unpleasant taste and do not dissolve in beverages.   

Kratom extract powder cannot be mixed into drinks as it is not water-soluble. Check out the following short video to learn more:

Water-Soluble Mitragynine

It is important to note that the solubility of mitragynine from kratom in neutral-pH and alkaline water is too low (0.0187 mg/ml at pH 9) )[1]. In acidic water, the solubility is higher (3.5 mg/ml at pH 4), however, mitragynine becomes unstable (10 % loss in 6 hours) )[1], so low-pH beverages have an extremely short shelf life. 

Instability of kratom extracts in beverages is a very common problem, often indicated by labels marked ‘shake well before consuming‘. Many vendors offer concentrated liquid kratom products (shots) with claims of improved mitragynine solubility, however, those products are based on solvents (mainly propylene glycol—the base ingredient of antifreeze) rather than water and tend to be extremely unpleasant (and unhealthy) to consume. 

Nanokinetics’ water-soluble mitragynine (commonly referred to as water-soluble kratom) is a nano-formulated alkaloid ingredient that is made into a powdered form. Our nano-emulsified powder technology allows us to produce effervescent kratom extract tablets that dissolve rapidly and completely in water (to full transparency and regardless of pH) or any other beverage and allow mitragynine to remain stable in any environment (before and after dissolution), preserving its structure and functionality. 

Water-Soluble Kratom Herbal Supplements

Water-soluble mitragynine from kratom is a game-changer in the world of herbal supplements, that is studied for its potential for providing multiple benefits. A typical serving of a kratom-based product contains around 50 mg of mitragynine, which most users report boosts energy and focus, making it ideal for competitive sports or general workouts. Users also report experiencing improved work capacity and alertness, increased sociability, and enhanced libido. 

At higher doses, kratom has been known to reduce anxiety and pain, alleviate fatigue and depression, and effectively treat opioid and alcohol withdrawal symptoms. Prolonged daily kratom use may lead to dependence. It is advised to not consume kratom products simultaneously with other drugs to avoid the possibility of serious side effects.

By utilizing Nanokinetics’ innovative powdered nano-emulsion formulations, water-soluble kratom benefits are maximized. 

Some of Nanokinetics’ water-soluble mitragynine powder benefits include: 

• Complete solubility in water or other beverages (to full transparency and regardless of pH)
• Stable in any environment (before and after dissolution)
• Nano-formulated using only mild food-grade ingredients
• Highly bioavailable and fast-acting with predictable and reproducible effects
• No artificial colors, sweeteners, flavors, or preservatives
• Sugar-free, vegan, and gluten-free

Water-soluble mitragynine is highly versatile and convenient to use, making it an ideal choice for businesses seeking a more efficient and effective way to incorporate kratom into their water-based products and reshape the landscape of kratom herbal supplements.

Exploring Mitragynine Effervescent Tablets  

Effervescent tablets offer a convenient and discreet way to consume water-soluble mitragynine from kratom, providing a portable solution for individuals looking to consume on the go. The effervescent nature of these tablets ensures quick dissolution, under 5 minutes, and pleasant taste, making them an ideal choice for those seeking fast-acting effects. 

Conclusion

Water-soluble mitragynine kratom offers a promising potential in performance enhancement products. Product developers and formulators can leverage Nanokinetics’ innovative solution to create finished products and supplements and it is perfectly optimized for nutraceuticals and beverages.

Discover the numerous therapeutic benefits of Nanokinetics® kratom formulations, which offer premium quality and efficacy by converting kratom into a water-soluble form.