Nanokinetics’ Coenzyme Q10 and Vitamin E Oral Nanoemulsion
Combating Aging Skin Odor
Explore the power of nanokinetics’ water-soluble CoQ10 and Vitamin E nano-formulation in combating aging skin odor
The Problem
Aging brings various changes to our bodies, some of which are less obvious yet significantly impactful. One such change is the production of 2-nonenal, a compound responsible for the distinctive odor often associated with aging skin. This article explores what 2-nonenal is, the issues it causes, and how Coenzyme Q10 (CoQ10) and Vitamin E included in Nanokinetics’ translucent oral nanoemulsion formulation can synergistically help reduce its formation. These nanoemulsions can be readily and conveniently infused into water or other beverages, making the administration of CoQ10 and Vitamin E both efficient and effective, as they are quickly and fully absorbed into the bloodstream.
What is 2-Nonenal?
2-Nonenal is an unsaturated aldehyde that forms through the oxidation of omega-7 fatty acids (e.g., palmitoleic acid), which are naturally present in the skin. As we age, the skin's capacity to regenerate and shield itself from oxidative stress diminishes, leading to increased oxidation of these fatty acids. This process results in the production of 2-nonenal, responsible for the characteristic, often unpleasant odor associated with aging skin, commonly referred to as "old person smell" [1].
Issues Caused by 2-Nonenal
The presence of 2-nonenal on the skin can lead to several concerns:
- Unpleasant Odor: The primary and most noticeable issue is the odor itself, which can be distressing, affecting self-esteem and social interactions.
- Increased Oxidative Stress: The formation of 2-nonenal signals heightened oxidative stress in the skin, leading to further skin damage, including wrinkles, loss of elasticity, and dryness.
- Skin Health Decline: The oxidation of skin lipids not only produces 2-nonenal but also contributes to the overall decline in skin health, making it more vulnerable to environmental damage.
The Role of Coenzyme Q10 and Vitamin E in Mitigating 2-Nonenal Formation
Coenzyme Q10, or CoQ10, is a naturally occurring antioxidant found in the mitochondria of cells. It plays a critical role in cellular energy production and shields cells from oxidative damage [2, 3]. However, as we age, CoQ10 levels in the body naturally decrease, reducing the skin's defense against oxidative stress, which contributes to the formation of 2-nonenal [4, 5].
Vitamin E, another powerful antioxidant, works synergistically with CoQ10 [6, 7]. It protects cell membranes from oxidative damage and is capable of regenerating itself after neutralizing free radicals, particularly when aided by CoQ10. This partnership not only amplifies the antioxidant effects but also provides comprehensive protection to the skin, reducing the formation of 2-nonenal and other oxidative stress markers.
By supplementing with CoQ10 and Vitamin E, one can enhance the skin's ability to combat oxidative stress, thereby reducing the oxidation of omega-7 fatty acids and the subsequent formation of 2-nonenal. This combination of ingredients not only helps neutralize free radicals but also regenerates other antioxidants, providing a robust defense for skin health.
Nanokinetics’ Nanoemulsion: The Best Way to Consume Coenzyme Q10 & Vitamin E
While CoQ10 and Vitamin E are both potent antioxidants, their effectiveness is often limited by poor bioavailability when consumed in traditional supplement forms, such as capsules or tablets [8, 9]. Both compounds are lipophilic (fat-soluble), meaning they are not easily absorbed into the bloodstream when ingested.
Nanokinetics’ nanoemulsion technology offers a solution to this problem. A nanoemulsion is a fine, stable mixture of oil and water where CoQ10 and Vitamin E molecules are encapsulated in tiny droplets with median sizes of about 25 - 30 nanometers. This form significantly enhances their bioavailability due to several factors:
- Increased Surface Area: The nano-sized droplets increase the surface area available for absorption in the digestive tract, leading to more efficient uptake of both CoQ10 and Vitamin E.
- Improved Solubility: Nanoemulsions enhance the aqueous solubility of CoQ10 and Vitamin E, making it easier for the body to absorb and utilize these compounds.
- Synergistic Absorption: When CoQ10 and Vitamin E are included together in a nanoemulsion, they work synergistically, enhancing each other's stability and effectiveness, leading to better protection against oxidative stress.
- Faster Absorption: Due to the small size of their droplets, nanoemulsions are absorbed into the bloodstream very quickly and completely, allowing CoQ10 and Vitamin E to reach skin cells faster and more effectively.
- Enhanced Stability: Nanoemulsions protect CoQ10 and Vitamin E from degradation in the digestive system, ensuring that greater amounts of these active compounds are delivered to where they are needed.
The formation of 2-nonenal on the skin is a natural, albeit undesirable, part of aging. It is closely tied to oxidative stress and the decline in skin health. However, with the help of Coenzyme Q10 and Vitamin E, particularly when consumed together in the form of a Nanokinetics’ translucent nanoemulsion, it is possible to mitigate the effects of 2-nonenal, improving both skin health and overall well-being. The enhanced bioavailability and synergistic effects offered by our nanoemulsion technology make it the superior choice for those looking to maximize the benefits of CoQ10 and Vitamin E supplementation in their fight against the signs of aging.
Welcome to Our Food-Grade
Highly Water-Soluble CoQ10 & Vitamin E
Achieve Rapid Solubility in Water or Any Other Beverage with Nanokinetics®
Nanokinetics® technology allows us to formulate CoQ10 into a fully water-compatible nanoemulsion. The enhanced bioavailability and synergistic effects offered by our nanoemulsion technology make it the superior choice for those looking to maximize the benefits of water-soluble CoQ10 and Vitamin E supplementation in their fight against the signs of aging.
References:
- Yamazaki, S., Hoshino, K., & Kusuhara, M. (2010). Odor associated with aging. Anti-Aging Medicine, 7(6), 60–65. https://doi.org/10.3793/jaam.7.60.
- Nagase, M., Yamamoto, Y., Matsumoto, N., Arai, Y., & Hirose, N. (2018). Increased oxidative stress and coenzyme q10 deficiency in centenarians. Journal of Clinical Biochemistry and Nutrition, 63(2), 129-136. https://doi.org/10.3164/jcbn.17.124.
- Knott, A., Achterberg, V., Smuda, C., Mielke, H., Sperling, G., Dunckelmann, K., … & Blatt, T. (2015). Topical treatment with coenzyme q10‐containing formulas improves skin's q10 level and provides antioxidative effects. BioFactors, 41(6), 383-390. https://doi.org/10.1002/biof.1239.
- Labarrade, F., Menon, G. K., Labourasse, L., Gondran, C., Cucumel, K., & Domloge, N. (2018). Significance of ubiad1 for epidermal keratinocytes involves more than coq10 synthesis: implications for skin aging. Cosmetics, 5(1), 9. https://doi.org/10.3390/cosmetics5010009.
- Iitani, K., Mori, H., Ichikawa, K., Toma, K., Arakawa, T., Iwasaki, Y., … & Mitsubayashi, K. (2023). Gas-phase biosensors (bio-sniffers) for measurement of 2-nonenal, the causative volatile molecule of human aging-related body odor. Sensors, 23(13), 5857. https://doi.org/10.3390/s23135857.
- Tasaki, E., Yamamoto, Y., & Iuchi, Y. (2023). Higher levels of the lipophilic antioxidants coenzyme q10 and vitamin e in long‐lived termite queens than in short‐lived workers. Insect Science, 31(1), 201-210. https://doi.org/10.1111/1744-7917.13217.
- Zhang, X., Tohari, A. M., Marcheggiani, F., Zhou, X., Reilly, J., Tiano, L., … & Shu, X. (2017). Therapeutic potential of co-enzyme q10 in retinal diseases. Current Medicinal Chemistry, 24(39). https://doi.org/10.2174/0929867324666170801100516.
- Vaiserman, A., Koliada, A., Zayachkivska, A., & Lushchak, O. (2020). Nanodelivery of natural antioxidants: an anti-aging perspective. Frontiers in Bioengineering and Biotechnology, 7. https://doi.org/10.3389/fbioe.2019.00447.
- 9. Ebhohimen, I. E., Okanlawon, T. S., Osagie, A., & Izevbigie, O. N. (2021). Vitamin e in human health and oxidative stress related diseases. Biochemistry. https://doi.org/10.5772/intechopen.99169.
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